Mud therapy, a completely natural treatment, is widely used in the fields of rheumatology, physiatry, and rehabilitation. Thermal muds, at the core of this treatment, prove to be a valuable resource for the prevention and treatment of symptoms related to osteoarthritis, as well as for numerous muscular, joint pathologies, and the aftermath of traumas and fractures. Scientific evidence demonstrates that the benefits of thermal muds result from the significant interaction of their components with inflammation mediators. Compared to non-steroidal anti-inflammatory drugs, thermal muds ensure more lasting results on muscle contractions and the reduction of painful symptoms.The physical properties of the mud give it the ability to trigger a progressive thermal exchange mechanism with the body in two different ways. When heated, the mud gradually releases accumulated heat, causing vasodilation that increases local circulation and the release of endorphins. If cooled at a low temperature, it absorbs heat from the application area, allowing a localized decrease in temperature and vasoconstriction. In both cases, the osmotic action triggered promotes the elimination of accumulated excess fluids in the skin tissues, offering an anti-edematous action and reducing the sensation of pain.In the therapeutic context, the hyperthermal salso, bromo, iodic muds from the Euganean Thermal Basin (B.T.E.) stand out as a unique resource, whose level of qualification has been recognized by the Ministry of Health.