The frigidarium held a central role in ancient baths, characterized by an extremely cold atmosphere using ice-cold water from natural sources. Immersion in this cold water revealed psychophysical therapeutic properties.Empirical knowledge evolved into scientific research, giving rise to cryotherapy. This technique harnesses the power of cold to stimulate diverse bodily reactions, providing rapid and lasting relief for various conditions. Commonly used for muscle pain, inflammation, tension, bruises, sprains, dislocations, and strains, cold application reduces inflammation, edema, limiting tissue damage, and accelerating healing. Additionally, cold decreases pain receptor sensitivity, offering immediate relief in early trauma stages.Beyond its analgesic effect, cryotherapy enhances blood circulation. Applied to the skin, cold induces temporary vasoconstriction, followed by vasodilation as the area returns to normal temperature. This process stimulates blood circulation, promoting nutrient and oxygen delivery to tissues, contributing to the healing process.Cryotherapy can also boost the immune system by stimulating endorphin production, natural chemicals with analgesic properties, and increasing cytokine production, key proteins in immune response regulation.Finally, cryotherapy proves effective in treating chronic inflammatory disorders like arthritis. Acting on joint inflammation, it reduces pain and improves mobility. Cryotherapy can be applied locally or generally, immersing the body in a cryogenic chamber.Building on thermal cryotherapy principles, Thermalis developed Criorex Emulgel®, a medical device for treating hematomas and trauma, offering an innovative and effective solution.